Table 4.
Focal cortical white matter volumes in children with PWS and healthy controls
|
PWS |
|
Control |
|
P
value between groups |
P
corr
value DEL versus control |
P
corr
value mUPD versus control |
P
corr
value mUPD versus DEL |
|||
|---|---|---|---|---|---|---|---|---|---|---|
|
DEL |
mUPD |
|
|
|
||||||
| Mean | SD | Mean | SD | Mean | SD | |||||
| Left pars orbitalis |
0.00057 |
0.00008 |
0.00055 |
0.00008 |
0.00064 |
0.00006 |
0.033 |
0.09 |
0.06 |
ns |
| Left superior frontal |
0.01242 |
0.0012 |
0.01101 |
0.00074 |
0.01284 |
0.00032 |
0.002 |
ns |
0.001 |
0.026 |
| Left precuneus |
0.00679 |
0.00098 |
0.00566 |
0.00096 |
0.00652 |
0.00065 |
0.025 |
ns |
ns |
0.021 |
| Right pars orbitalis |
0.0008 |
0.00013 |
0.00070 |
0.00008 |
0.00088 |
0.00011 |
0.005 |
ns |
0.003 |
0.127 |
| Right pars triangularis |
0.00217 |
0.00031 |
0.00190 |
0.00035 |
0.0023 |
0.00038 |
0.014 |
ns |
0.043 |
ns |
| Right caudal anterior cingulate |
0.00235 |
0.00024 |
0.00237 |
0.00015 |
0.00219 |
0.00034 |
0.011 |
ns |
ns |
0.008 |
| Right posterior cingulate |
0.00319 |
0.00025 |
0.00198 |
0.00022 |
0.00314 |
0.00026 |
0.008 |
ns |
0.044 |
0.010 |
| Right precuneus | 0.00736 | 0.00125 | 0.00282 | 0.00089 | 0.00678 | 0.00079 | 0.042 | ns | ns | 0.036 |
All measures presented in table are corrected for TIV. Pcorr values that did not survive the Bonferroni correction are included. DEL, deletion; mUPD, maternal uniparental disomy; ns, not significant; PWS, Prader–Willi syndrome; SD, standard deviation; TIV, total intracranial volume.