Figure 5. Effect of cilostazol (50 & 100 mg/kg; Cilo₅₀& Cilo₁₀₀), pioglitazone (3 & 10 mg/kg; Pio₃ & Pio₁₀), and their combination (Cilo₅₀& Pio₃) on the renal content of (A) IL-18, (B) caspase-1 and (C) NF-κBin rats subjected to ischemia (45 min)/reperfusion (24 hrs).

Drugs were administered orally for 14 days then subjected to ischemia/reperfusion. Values are expressed as mean ± S.E.M (n = 6). Data are compared with sham operated control (#), I/R control (*), Cilo₅₀ (†), Pio₃ (‡), and combination (§) pretreated groups (one-way ANOVA followed by Tukey Multiple Comparison Test) at P<0.05.