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. 2013 Oct 19;12:147. doi: 10.1186/1476-511X-12-147

Table 3.

Erythrocyte membrane fatty acid composition in LZR and OZR rats fed CON, FLAX, FISH, or SDA diets for 12 weeks

Fatty acid ( % of total )
 Lean
 Obese
 Main effects
  
  CON FLAX FISH SDA CON FLAX FISH SDA Genotype Diet Interaction
LA [18:2(n-6)]
9.50 ± 0.28
 9.61 ± 0.28
 9.72 ± 0.28
 8.26 ± 0.29
 7.76 ± 0.30
 7.97 ± 0.29
 8.21 ± 0.29
 6.73 ± 0.31
 P < 0.0001†
 P < 0.0001i
 P = 0.96
ALA [18:3(n-3)]
0.04 ± 0.07a
 0.43 ± 0.07b
 0.10 ± 0.07a
 0.64 ± 0.07c
 0.14 ± 0.07a
 0.70 ± 0.07c
 0.21 ± 0.07a
 0.61 ± 0.08bc
 P = 0.24
 P < 0.0001ii
 ΔP = 0.079
GLA [18:3(n-3)]
0.04 ± 0.02
 0.04 ± 0.02
 0.04 ± 0.02
 0.30 ± 0.02
 0.05 ± 0.02
 0.04 ± 0.02
 0.04 ± 0.02
 0.20 ± 0.02
 P = 0.78
 P < 0.0001iii
 P = 0.52
SDA [18:4(n-3)]
0.03 ± 0.05
 0.03 ± 0.05
 0.03 ± 0.05
 0.40 ± 0.05
 0.03 ± 0.03
 0.02 ± 0.05
 0.03 ± 0.05
 0.40 ± 0.05
 P = 0.74
 P < 0.0001iii
 P = 0.76
AA [20:4(n-6)]
25.63 ± 0.51
 22.21 ± 0.51
 15.90 ± 0.50
 20.67 ± 0.52
 24.91 ± 0.54
 21.1 ± 0.51
 14.80 ± 0.52
 18.13 ± 0.56
 P = 0.056
 P < 0.0001iv
 P = 0.13
EPA [20:5(n-3)]
0.05 ± 0.11a
 1.06 ± 0.11b
 5.14 ± 0.11f
 2.80 ± 0.11d
 0.23 ± 0.12a
 1.45 ± 0.11c
 5.41 ± 0.12f
 3.98 ± 0.12e
 P = 0.0017‡
 P < 0.0001v
 ΔP < 0.0001
DPA [22:5(n-3)]
1.02 ± 0.16a
 3.67 ± 0.16cd
 3.74 ± 0.16d
 5.44 ± 0.17e
 1.19 ± 0.17a
 3.08 ± 0.17b
 3.17 ± 0.18bc
 4.64 ± 0.18e
 P = 0.052
 P < 0.0001vi
 ΔP = 0.0050
DHA [22:6(n-3)]
2.51 ± 0.14
 3.74 ± 0.14
 5.80 ± 0.14
 2.31 ± 0.14
 2.91 ± 0.15
 4.33 ± 0.14
 6.50 ± 0.14
 3.28 ± 0.15
 P = 0.0010‡
 P < 0.0001vii
 P = 0.10
∑SFA
 47.53 ± 0.39
 47.58 ± 0.39
 47.17 ± 0.38
 47.49 ± 0.40
 47.35 ± 0.41
 47.23 ± 0.39
 47.67 ± 0.40
 47.31 ± 0.43
 P = 0.93
 P = 0.99
 P = 0.56
∑MUFA
 9.62 ± 0.39
 9.94 ± 0.39
 11.00 ± 0.39
 10.14 ± 0.40
 11.91 ± 0.42
 12.12 ± 0.40
 12.12 ± 0.40
 12.36 ± 0.43
 P = 0.0006‡
 P = 0.11
 P = 0.23
∑n3PUFA
 3.63 ± 0.19
 8.92 ± 0.19
 14.81 ± 0.19
 11.63 ± 0.20
 4.48 ± 0.20
 9.59 ± 0.19
 15.31 ± 0.20
 12.88 ± 0.21
 P = 0.0029‡
 P < 0.0001v
 P = 0.10
∑n6PUFA 41.23 ± 0.45 37.23 ± 0.45 32.76 ± 0.44 33.01 ± 0.46 38.61 ± 0.48 35.33 ± 0.45 31.33 ± 0.46 30.67 ± 0.49 P = 0.0013† P < 0.0001iv P = 0.41

ΔDifferent letters represent significance among means as determined by Bonferroni correction (P < 0.05).

Genotype Effect: †Lean > Obese; ‡Obese > Lean.

Diet Effect: iCON, FLAX, FISH > SDA; iiSDA, FLAX > CON, FISH; iiiSDA > CON, FLAX, FISH; ivCON > FLAX > SDA > FISH; vFISH > SDA > FLAX > CON; viSDA > FLAX, FISH > CON; viiFISH > FLAX > SDA, CON.