Table 5.
Hepatic transcript abundance in LZR and OZR rats fed CON, FLAX, FISH, or SDA diets for 12 weeks
Gene symbol |
Gene name |
Ref. Seq. # |
Lean |
Obese |
|||||
---|---|---|---|---|---|---|---|---|---|
FLAX | FISH | SDA | CON | FLAX | FISH | SDA | |||
Scd1 |
Stearoyl coenzyme A desaturase 1 |
NM_139192 |
1.58a |
1.25a |
0.43a |
8.80b |
10.10b |
1.49a |
7.27b |
Fads1 |
Fatty acid desaturase 1 (Δ5 desaturase) |
NM_053445 |
4.92b |
2.14a |
0.95a |
3.49b |
3.58b |
3.03ab |
2.43ab |
Fads2 |
Fatty acid desaturase 2 (Δ6 desaturase) |
NM_031344 |
3.44b |
2.20a |
1.01a |
3.86b |
4.54c |
3.57b |
3.62b |
Elovl5 |
Elongation of very long chain fatty acids 5 |
NM_134382 |
4.41b |
1.81a |
0.96a |
2.81ab |
4.23b |
2.28a |
2.12a |
Elovl6 |
Elongation of very long chain fatty acids 6 |
NM_134383 |
1.94b |
0.75a |
0.45a |
17.39c |
50.01d |
11.17c |
22.84c |
Acox1 |
Acyl coenzyme A oxidase 1 |
NM_017340 |
1.54a |
1.48a |
2.23ab |
1.64a |
2.22ab |
2.45b |
2.54b |
PPARα | Peroxisome proliferator activated receptor α | NM_013196 | 2.38a | 1.04a | 1.00a | 4.14b | 4.81b | 4.56b | 3.94b |
Data are expressed as fold change relative to LZR rats fed control diet. Letters represent significance difference among treatments groups as determined by comparison of normalized Ct values (target Ct - housekeeping Ct) with paired t test.