Table 9.

Brain fatty acid profile in LZR and OZR rats fed CON, FLAX, FISH, or SDA diets for 12 week

Fatty acid ( % of total )	Lean				Obese				Main effect
	CON	FLAX	FISH	SDA	CON	FLAX	FISH	SDA	Genotype	Diet	Interaction
LA [18:2(n-6)]	0.005 ± 0.002	0.009 ± 0.002	0.005 ± 0.002	0.009 ± 0.002	0.007 ± 0.002	0.007 ± 0.001	0.010 ± 0.002	0.012 ± 0.002	P = 0.13	P = 0.48	P = 0.35
ALA [18:3(n-3)]	1.31 ± 0.030	1.36 ± 0.030	1.28 ± 0.028	1.23 ± 0.030	1.19 ± 0.030	1.20 ± 0.024	1.16 ± 0.030	1.05 ± 0.030	P < 0.0001†	P < 0.0001i	P = 0.58
SDA [18:4(n-3)]	0.16 ± 0.027	0.14 ± 0.027	0.18 ± 0.026	0.18 ± 0.027	0.08 ± 0.028	0.10 ± 0.022	0.13 ± 0.027	0.12 ± 0.027	P = 0.078	P = 0.30	P = 0.83
AA [20:4(n-6)]	11.02 ± 0.20de	10.69 ± 0.20cd	9.80 ± 0.19b	10.65 ± 0.20cd	11.19 ± 0.21e	10.27 ± 0.16bc	8.87 ± 0.20a	10.48 ± 0.20cd	P = 0.16	P < 0.0001ii	ΔP = 0.021
EPA [20:5(n-3)]	0.023 ± 0.01a	0.028 ± 0.01a	0.13 ± 0.01c	0.079 ± 0.01b	0.018 ± 0.01a	0.066 ± 0.0b	0.24 ± 0.01e	0.20 ± 0.01d	P < 0.0001‡	P < 0.0001iii	ΔP < 0.0001
DPA [22:5(n-3)]	0.13 ± 0.018a	0.28 ± 0.018b	0.46 ± 0.017c	0.66 ± 0.018e	0.13 ± 0.018a	0.33 ± 0.014b	0.56 ± 0.018d	0.81 ± 0.018f	P = 0.0009‡	P < 0.0001iv	ΔP < 0.0001
DHA [22:6(n-3)]	12.80 ± 0.22	13.53 ± 0.21	14.38 ± 0.21	13.53 ± 0.22	13.52 ± 0.22	13.61 ± 0.17	15.06 ± 0.22	13.90 ± 0.22	P = 0.077‡	P < 0.0001v	P = 0.26
∑SFA	36.00 ± 0.27	35.78 ± 0.26	35.74 ± 0.25	35.73 ± 0.26	36.35 ± 0.27	36.06 ± 0.21	35.77 ± 0.26	36.83 ± 0.27	P = 0.16	P = 0.074vi	P = 0.091
∑MUFA	19.90 ± 0.16	20.44 ± 0.15	20.84 ± 0.15	20.1 ± 0.15	19.61 ± 0.16	20.08 ± 0.12	20.03 ± 0.15	19.82 ± 0.16	P = 0.021†	P < 0.0001vii	P = 0.14
∑n3PUFA	14.62 ± 0.21	15.53 ± 0.20	16.61 ± 0.19	15.85 ± 0.20	15.08 ± 0.21	15.46 ± 0.16	17.23 ± 0.20	16.29 ± 0.21	P = 0.14	P < 0.0001iii	P = 0.21
∑n6PUFA	11.02 ± 0.20bd	10.70 ± 0.20b	9.80 ± 0.19b	10.65 ± 0.20bc	11.20 ± 0.21d	10.28 ± 0.16c	8.88 ± 0.20a	10.49 ± 0.20b	P = 0.17	P < 0.0001ii	ΔP = 0.023

^ΔDifferent letters represent significance among means as determined by Bonferroni correction (P < 0.05).

Genotype Effect: ^†Lean > Obese; ^‡Obese > Lean.

Diet Effect: ⁱFLAX > CON > FISH > SDA; ⁱⁱCON > FLAX, SDA > FISH; ⁱⁱⁱFISH > SDA > FLAX > CON; ^ivSDA > FISH > FLAX > CON; ^vFISH > SDA, FLAX > CON; ^viSDA, CON > FISH, FLAX; ^viiFISH, FLAX > SDA, CON.