Table 3.

Association of SNP alleles considering either all cases or early-onset cases only for the narrow definition of schizophrenia, bipolar disorder and the common locus phenotype in the kindred sample

Marker	Alleles		MAFa			All cases vs NAARs		Early-onset cases vs NAARs
	Min.	Maj.	cases		NAARsb (n=467)	ORc (95% CI)	Pd	ORc (95% CI)	Pd
			All	Early-onsete
Schizophrenia (119 cases, 58 early-onset cases)
rs2120753	G	A	0.429	0.377	0.484	0.80 (0.58, 1.11)	0.18	0.65 (0.42, 1.01)	0.054
rs1156026	T	C	0.538	0.638	0.436	1.54 (1.1, 2.17)	0.012	2.40 (1.53, 3.76)	1.3e-4
Bipolar disorder (117 cases, 40 early-onset cases)
rs2120753	G	A	0.461	0.382	0.484	0.92 (0.65, 1.29)	0.61	0.66 (0.38, 1.16)	0.15
rs1156026	T	C	0.449	0.512	0.436	1.06 (0.75, 1.48)	0.76	1.37 (0.76, 2.44)	0.29
Common locus phenotype (273 cases, 118 early-onset cases)
rs2120753	G	A	0.458	0.396	0.484	0.90 (0.73, 1.12)	0.37	0.71 (0.52, 0.95)	0.023
rs1156026	T	C	0.487	0.589	0.436	1.24 (0.98, 1.56)	0.075	1.87 (1.37, 2.55)	8.1e-5

^aMinor allele frequency.

^bNon-affected adult relatives

^cGEE OR estimate and its 95% CI calculated using the empirical variance estimate.

^dP-value of Wald test calculated using the empirical variance estimate.

^eonset before age 26