FIGURE 11.

Memory CD8⁺ T cells from FasL mutant mice fail to confer protection. WT and FasL mutant mice were infected with LM (1 × 10³, i.v.). On day 80, CD8⁺ T cells were purified from naive and LM-OVA-infected mice. Purified CD8⁺ T cells from WT or FasL mutant mice were transferred (2 × 10⁶) into naive WT or FasL mutant recipients. Four days after the transfer, recipients were challenged with a lethal dose (3 × 10⁵) of LM-OVA. LM-OVA burden in the spleens was evaluated after 3 days.