Figure 5.

Schematic summarizing the activation and turnover of LKB1 in a polarizing neuron as it transits along a radial glial fiber. STRADα shuttles from the cytoplasm to the nucleus (1). At least two possible outcomes exist for nuclear LKB1 either binding to STRADα (2) or degradation via the proteasome (3). Once exported by STRADα to the cytoplasm, LKB1 can drive axogenesis (4) by either remaining bound to STRADα or by binding STRADβ. In the latter case, STRADα may return to the nucleus once again (5).