Table 2:
Outcomes at 6 months: intention-to-treat analysis
| Variable | No. (%) or mean ± SD | Difference (intervention – control), SD* (95% CI) | |
|---|---|---|---|
| Pharmacist-led group n = 143 |
Nurse-led group n = 136 |
||
| At guideline-recommended systolic blood pressure level at baseline | 91 (63.6) | 85 (62.5) | 1.1% (−10.8 to 13.1) |
| At guideline-recommended lipid level at baseline | 8 (5.6) | 7 (5.2) | 0.4% (−5.0 to 5.6) |
| Attained guideline-recommended systolic blood pressure level by 6 mo | 115 (80.4) | 122 (89.7) | −9.3% (−17.0 to −0.2) |
| Attained guideline-recommended LDL level by 6 mo | 73 (51.1) | 46 (33.8) | 17.2% (4.9 to 29.0) |
| Primary outcome | |||
| Attained optimal systolic blood pressure and lipid level by 6 mo | 62 (43.4) | 42 (30.9) | 12.5% (0.4 to 24.0) |
| Secondary outcomes | |||
| Systolic blood pressure at 6 mo | 126.5 ± 17.9 | 122.2 ± 13.0 | 4.3 (0.6 to 8.0) |
| LDL cholesterol at 6 mo | 2.21 ± 0.73 | 2.35 ± 0.81 | −0.14 (−0.32 to 0.04) |
| Change in systolic blood pressure over 6 mo | −8.1 ± 16.0 | −11.4 ± 16.3 | 3.3 (0.5 to 7.1) |
| Change in LDL over 6 mo | −0.98 ± 0.96 | −0.90 ± 0.90 | −0.7 (−0.30 to 0.16) |
| Mortality | 0 (0) | 1 (0.7) | −0.7% (−0.7 to 0.6) |
| Vascular event† | 9 (6.3) | 8 (5.9) | 0.4% (−5.4 to 6.0) |
| Change in HDL cholesterol | −0.01 ± 0.23 | −0.04 ± 0.19 | 0.03 (−0.02 to 0.08) |
| Change in total:HDL ratio | −1.13 ± 1.13 | −1.03 ± 1.07 | −0.10 (−0.36 to 0.16) |
| Self-reported adherence of 75% or higher for blood pressure or lipid-lowering medications | 138 (96.5) | 132 (97.1) | −0.6% (−4.3 to 3.7) |
| Change in body mass index | −0.20 ± 1.39 | −0.09 ± 3.3 | −0.11 (−0.70 to 0.48) |
| Current smokers at baseline who stopped during 6-mo period | 4/24 (16.7) | 6/16 (37.5) | −20.8% (−46.9 to 10.5) |
| Overall self-rated health‡ | 3.5 ± 0.9 | 3.4 ± 0.8 | 0.1 (−0.1 to 0.3) |
| EQ-5D index score | 0.84 ± 0.15 | 0.86 ± 0.17 | −0.02 (−0.06 to 0.02) |
| Overall rating of health care satisfaction‡ | 4.35 ± 0.92 | 4.40 ± 0.79 | −0.05 (−0.25 to 0.15) |
| Physical activity meets Canadian guidelines§ | 11 (10.1) | 6 (4.8) | 3.3% (−2.9 to 8.1) |
Note: CI = confidence interval, EQ-5D = EuroQol Health Questionnaire, HDL = high-density lipoprotein, LDL = low-density lipoprotein, SD = standard deviation.
*
Unless otherwise stated.
†
Myocardial infarction, stroke or transient ischemic attack, coronary or carotid revascularization.
‡
Scored on a 5-point Likert scale with 5 being excellent and 1 being poor.
§
Individuals reporting at least 120 minutes of moderate or strenuous physical activity per week.