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Activation of a 'fibrotic program’ in allogeneically transplanted grafts. (A,B) PCR array using RNA extracted from explanted hearts (day 100) of allogeneically (FVB into DBA/1) or syngeneically (DBA/1 into DBA/1) transplanted mice demonstrated an upregulation of pro-fibrotic genes and a downregulation of anti-fibrotic genes in the allogeneic group.
