Table 2.
Associations between moderate to vigorous intensity physical activity (MVPA) and cancer mortality in the NIH-AARP study population (N=293,511)a
| MVPA (h/wk) | Never/rare | <1 | 1–3 | 4–7 | >7 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cancer death | No. of deaths | HR (ref.) | No. of deaths | HR (95% CI) | No. of deaths | HR (95% CI) | No. of deaths | HR (95% CI) | No. of deaths | HR (95% CI) | P trend |
| All cancers | 2524 | 1.00 | 1659 | 0.95 (0.89–1.01) | 3756 | 0.93 (0.88–0.98) | 3636 | 0.90 (0.85–0.95) | 3426 | 0.89 (0.84–0.94) | <0.001 |
| Individual cancer sites by inverse magnitude of point estimate comparing MVPA >7 h/wk to never/rare MVPA | |||||||||||
| Lymphocytic leukemia | 20 | 1.00 | 14 | 0.96 (0.48–1.89) | 46 | 1.30 (0.76–2.21) | 24 | 0.65 (0.35–1.19) | 24 | 0.68 (0.37–1.25) | 0.058 |
| Colonb | 198 | 1.00 | 109 | 0.80 (0.63–1.01) | 268 | 0.85 (0.70–1.02) | 250 | 0.79 (0.65–0.96) | 211 | 0.70 (0.57–0.85) | <0.001 |
| Liver | 82 | 1.00 | 43 | 0.79 (0.54–1.14) | 112 | 0.90 (0.68–1.21) | 78 | 0.64 (0.47–0.88) | 82 | 0.71 (0.52–0.98) | 0.012 |
| Oral cavity and pharynx | 38 | 1.00 | 20 | 0.83 (0.48–1.44) | 41 | 0.79 (0.51–1.24) | 38 | 0.76 (0.48–1.21) | 36 | 0.75 (0.47–1.20) | 0.217 |
| Non-Hodgkins lymphoma | 104 | 1.00 | 90 | 1.19 (0.90–1.58) | 137 | 0.76 (0.58–0.98) | 154 | 0.83 (0.64–1.06) | 143 | 0.80 (0.62–1.04) | 0.017 |
| Esophagus | 88 | 1.00 | 55 | 0.92 (0.65–1.29) | 123 | 0.91 (0.69–1.20) | 127 | 0.96 (0.73–1.27) | 98 | 0.80 (0.60–1.08) | 0.251 |
| Myeloma | 61 | 1.00 | 34 | 0.75 (0.49–1.14) | 63 | 0.56 (0.40–0.81) | 90 | 0.77 (0.55–1.07) | 93 | 0.82 (0.59–1.15) | 0.579 |
| Lung | 923 | 1.00 | 522 | 0.85 (0.76–0.95) | 1258 | 0.92 (0.84–1.00) | 1095 | 0.82 (0.75–0.90) | 1073 | 0.84 (0.77–0.92) | <0.001 |
| Myeloid/monocytic leukemia | 54 | 1.00 | 50 | 1.27 (0.86–1.86) | 81 | 0.85 (0.60–1.21) | 109 | 1.10 (0.79–1.54) | 82 | 0.86 (0.60–1.22) | 0.346 |
| Stomach | 49 | 1.00 | 34 | 1.00 (0.65–1.56) | 77 | 0.99 (0.69–1.42) | 76 | 0.97 (0.67–1.40) | 68 | 0.90 (0.61–1.31) | 0.541 |
| Ovarianc | 61 | 1.00 | 41 | 0.92 (0.62–1.36) | 90 | 0.83 (0.59–1.15) | 98 | 0.87 (0.63–1.21) | 97 | 0.91 (0.65–1.26) | 0.623 |
| Prostate | 80 | 1.00 | 55 | 0.97 (0.69–1.37) | 107 | 0.79 (0.59–1.06) | 145 | 1.03 (0.78–1.37) | 126 | 0.93 (0.69–1.24) | 0.968 |
| Bladder | 52 | 1.00 | 45 | 1.25 (0.84–1.86) | 82 | 0.97 (0.68–1.38) | 82 | 0.95 (0.67–1.36) | 85 | 1.03 (0.72–1.46) | 0.698 |
| Breastb,c | 70 | 1.00 | 55 | 1.21 (0.82–1.80) | 103 | 0.92 (0.65–1.29) | 99 | 0.97 (0.68–1.37) | 109 | 1.08 (0.76–1.53) | 0.973 |
| Brain | 57 | 1.00 | 51 | 1.14 (0.78–1.66) | 115 | 1.03 (0.75–1.42) | 107 | 0.91 (0.65–1.26) | 128 | 1.14 (0.82–1.56) | 0.791 |
| Endometrialc,d | 23 | 1.00 | 24 | 1.52 (0.85–2.69) | 27 | 0.79 (0.45–1.38) | 35 | 1.13 (0.66–1.93) | 34 | 1.21 (0.70–2.08) | 0.745 |
| Pancreas | 149 | 1.00 | 145 | 1.35 (1.07–1.70) | 292 | 1.14 (0.93–1.39) | 338 | 1.28 (1.05–1.56) | 315 | 1.25 (1.03–1.53) | 0.065 |
| Kidney | 47 | 1.00 | 36 | 1.10 (0.71–1.70) | 85 | 1.14 (0.80–1.64) | 106 | 1.47 (1.03–2.09) | 93 | 1.42 (0.98–2.03) | 0.016 |
| Rectum | 18 | 1.00 | 16 | 1.26 (0.64–2.48) | 47 | 1.57 (0.90–2.71) | 39 | 1.27 (0.72–2.25) | 48 | 1.63 (0.93–2.84) | 0.150 |
a
Models are adjusted for sex, BMI (categories), education, race, alcohol (categories of 0, 0<–<3, and 3+ drinks/day), Healthy Eating Index-2010 score, calories, marriage status, diabetes, and smoke level (6 categories describing status and dose)
b
Additionally adjusted for screening in the three years prior to questionnaire.
c
Additionally adjusted for hormone therapy use and age at menarche.
d
Excluded women who reported a hysterectomy.