Table 3.
Associations for a one hour increase in moderate to vigorous intensity physical activity (MVPA) per week and cancer mortality in the NIH-AARP study population, stratified by smoking status (N=293,511)a
| Type of cancer death | Total population | Never smokers | Ever Smokers | P-interaction | |||
|---|---|---|---|---|---|---|---|
| No. of events | HR (95% CI) | No. of events | HR (95% CI) | No. of events | HR (95% CI) | ||
| All cancers | 15001 | 0.99 (0.98–0.99)b | 3200 | 0.99 (0.98–1.00) | 11,801 | 0.99 (0.98–0.99)b | 0.782 |
| Lymphocytic leukemia | 128 | 0.93 (0.88–0.99)b | 39 | 0.90 (0.81–1.00)b | 89 | 0.95 (0.88–1.02) | 0.744 |
| Colon | 1036 | 0.97 (0.95–0.99)b | 309 | 0.98 (0.94–1.01) | 727 | 0.96 (0.94–0.98)b | 0.507 |
| Liver | 397 | 0.96 (0.93–0.99)b | 118 | 0.92 (0.87–0.98)b | 279 | 0.98 (0.94–1.02) | 0.112 |
| Oral cavity and pharynx | 173 | 0.98 (0.93–1.02) | 25 | 0.93 (0.81–1.06) | 148 | 0.98 (0.93–1.04) | 0.597 |
| Non-Hodgkins lymphoma | 628 | 0.97 (0.95–1.00)b | 218 | 0.96 (0.92–1.01) | 410 | 0.98 (0.95–1.01) | 0.606 |
| Esophagus | 491 | 0.98 (0.96–1.01) | 62 | 0.96 (0.89–1.05) | 429 | 0.99 (0.96–1.02) | 0.635 |
| Myeloma | 341 | 1.01 (0.97–1.04) | 121 | 1.02 (0.96–1.08) | 220 | 1.00 (0.96–1.05) | 0.840 |
| Lung | 4871 | 0.98 (0.98–0.99)b | 252 | 1.00 (0.96–1.04) | 4619 | 0.98 (0.97–0.99)b | 0.454 |
| Myeloid leukemia | 376 | 0.99 (0.95–1.02) | 100 | 0.99 (0.93–1.06) | 276 | 0.98 (0.95–1.02) | 0.884 |
| Stomach | 304 | 0.99 (0.95–1.02) | 74 | 0.98 (0.91–1.05) | 230 | 0.99 (0.95–1.04) | 0.745 |
| Ovarianc | 387 | 1.00 (0.97–1.03) | 184 | 1.04 (0.99–1.09) | 203 | 0.96 (0.92–1.01) | 0.022 |
| Prostate | 513 | 1.01 (0.98–1.03) | 132 | 0.98 (0.93–1.04) | 381 | 1.01 (0.98–1.05) | 0.258 |
| Bladder | 346 | 0.99 (0.96–1.03) | 60 | 0.94 (0.87–1.03) | 286 | 1.00 (0.97–1.04) | 0.433 |
| Breastc | 436 | 1.01 (0.98–1.04) | 189 | 0.99 (0.95–1.04) | 247 | 1.02 (0.98–1.06) | 0.653 |
| Brain | 458 | 1.01 (0.98–1.04) | 166 | 1.02 (0.97–1.07) | 292 | 1.00 (0.96–1.03) | 0.335 |
| Endometrial | 146 | 1.02 (0.97–1.07) | 73 | 1.02 (0.94–1.09) | 73 | 1.02 (0.94–1.09) | 0.791 |
| Pancreas | 1239 | 1.02 (1.00–1.03) | 370 | 1.00 (0.96–1.03) | 869 | 1.02 (1.00–1.05)b | 0.314 |
| Kidney | 367 | 1.04 (1.01–1.08)b | 99 | 1.07 (1.00–1.14)b | 268 | 1.03 (0.99–1.08) | 0.598 |
| Rectum | 168 | 1.03 (0.98–1.08) | 49 | 0.99 (0.91–1.09) | 119 | 1.04 (0.99–1.11) | 0.385 |
a
Models are adjusted for sex, body mass index, education, race, alcohol intake, Healthy Eating Index-2010 score, calories, marriage status, diabetes and smoking intensity (where appropriate).
b
Significant at a p<0.05 level
c
Additionally adjusted for hormone therapy use and age at menarche.