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. Author manuscript; available in PMC: 2014 Nov 8.
Published in final edited form as: Nature. 2014 Mar 26;509(7499):183–188. doi: 10.1038/nature13135

Figure 2. FXR contributes to the maintenance of weight loss following VSG.

Figure 2

Both WT and FXR KO mice A) weighed more than 30g and B) carried more than 30% of their weight as fat prior to the surgery. C) WT-VSG mice lose weight and maintain this weight loss, relative to WT-sham controls, whereas D) KO-VSG mice recover the initial weight loss within 5 weeks after surgery, relative to KO-sham controls. E) 11-weeks following surgery, WT-VSG mice carry half the body fat of WT-sham mice whereas the body fat of KO-VSG and KO-sham mice is equivalent. F) 11-weeks following surgery, WT-VSG mice have lost 41% of their pre-surgical body fat, whereas KO-VSG mice exhibit no significant fat loss. Data are shown as mean ± SE. *= p< 0.05, ** = p< 0.01, *** = p< 0.001. For panels A-D, n= 12 WT-sham, 8 WT-VSG, 9 KO-sham, 8 KO-VSG. For panels E-F, n= 12 WT-sham, 9 WT-VSG, 9 KO-sham, 10 KO-VSG.