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. Author manuscript; available in PMC: 2014 Nov 8.
Published in final edited form as: Nature. 2014 Mar 26;509(7499):183–188. doi: 10.1038/nature13135

Extended Data Figure 1. Body weight and body fat in a weight-matched subset of WT and FXR KO mice.

Extended Data Figure 1

These posthoc analyses include the lightest 9 WT and heaviest 8 FXR-KO mice prior to surgery, creating 4 well-matched groups. In this subset, (A) WT-VSG lose weight relative to WT-sham controls, and maintain this weight loss for 14 weeks, whereas (B) KO-VSG mice lose weight initially, but recover to match the weight of KO-sham controls within 4-5 weeks. Likewise (C-D) these groups were well-matched for pre-surgical body fat. At 11 weeks after surgery, WT-VSG mice had significantly less body fat compared to both WT-sham controls and KO-VSG mice. KO-sham and KO-VSG mice had equivalent adiposity. Data are shown as mean ± SE. *= p< 0.05, ** = p< 0.01, *** = p< 0.001. n= 5 WT-sham, 4 WT-VSG, 4 KO-sham, 4 KO-VSG.