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. 2014 May 9;9(5):e96938. doi: 10.1371/journal.pone.0096938

Figure 2. USAG-1 antagonises BMP-7 in maxillary supernumerary incisors formation.

Figure 2

Sagittal sections of E15 (A–D) embryos and frontal sections of mice on the day of birth (E–H). (A’–H’) Higher magnification of the boxed regions in (A–H). USAG-1+/+/BMP-7+/+, (A, A’, E, E’); USAG-1−/−/BMP-7+/+, (B, B’, F, F’); USAG-1+/+/BMP-7−/−, (C, C’, G, G’) and USAG-1−/−/BMP-7−/− (D, D’, H, H’). The area of rudimentary incisor was measured in transverse sections of USAG-1+/+/BMP-7+/+ (white bars), USAG-1−/−/BMP-7+/+ (right grey bars), USAG-1+/+/BMP-7−/− (dark grey bars) and USAG-1−/−/BMP-7−/− (black bars) mice (n = 5) in E15 (I) and P0 (J). At E15, the area of the maxillary deciduous incisor was identified in wild type as well as all mutant mice in the labial border of the epithelial invagination. The size of rudimentary incisor is similar except USAG-1+/+/BMP-7−/− at E15 (A, A’, B, B’, C, C’, D, D’ and I).Rudimentary tooth primordia in USAG-1−/−/BMP-7−/− and USAG-1+/+/BMP-7+/+ regressed and its size became smaller at birth, whereas the teeth in USAG-1−/−/BMP-7+/+ continued to develop and enamel organ was formed (E, E’, F, F’, H, H’ and J).