Table 1. Effects of PTPN22 SNPs on VKH syndrome risk.
Genotype | VKH | Controls | P value | Pc value | OR (95%CI) | ||
N = 1005 | N = 2010 | ||||||
rs2488457 | N | % | N | % | |||
GG | 102 | 10.1 | 310 | 15.4 | 7.06×10−5 | 6.35×10−4 | 0.62(0.49–0.79) |
CG | 454 | 45.2 | 1009 | 51.2 | 0.009 | NS | 0.82(0.70–0.95) |
CC | 449 | 44.7 | 691 | 34.4 | 3.86×10−8 | 3.47×10−7 | 1.54(1.32–1.80) |
G Allele | 658 | 32.7 | 1629 | 40.5 | 4.25×10−9 | 3.83×10−8 | 0.71(0.64–0.80) |
C Allele | 1352 | 67.3 | 2391 | 59.5 | 4.25×10−9 | 3.83×10−8 | 1.40(1.25–1.57) |
rs1310182 | |||||||
CC | 48 | 4.8 | 84 | 4.2 | 0.450 | NS | 1.15(0.80–1.65) |
CT | 292 | 29 | 589 | 29.3 | 0.887 | NS | 0.99(0.84–1.17) |
TT | 665 | 66.2 | 1337 | 66.5 | 0.849 | NS | 0.99(0.84–1.16) |
C Allele | 388 | 19.3 | 757 | 18.8 | 0.659 | NS | 1.03(0.90–1.18) |
T Allele | 1622 | 80.7 | 3263 | 81.2 | 0.659 | NS | 0.97(0.85–1.11) |
rs3789604 | |||||||
TT | 648 | 64.5 | 1254 | 62.4 | 0.262 | NS | 1.09(0.94–1.28) |
GT | 303 | 30.1 | 651 | 32.4 | 0.231 | NS | 0.90(0.77–1.06) |
GG | 54 | 5.4 | 105 | 5.2 | 0.863 | NS | 1.03(0.74–1.44) |
T Allele | 1599 | 79.6 | 3159 | 78.6 | 0.384 | NS | 1.06(0.96–1.21) |
G Allele | 411 | 20.4 | 861 | 21.4 | 0.384 | NS | 0.94(0.83–1.08) |
Pc = Bonferroni corrected P value. NS = Not significant. OR = odds ratio. 95% CI = 95% confidence interval.