Table 2.

SNPs associated with bladder cancer risk in the Los Angeles-Shanghai study

Pathway	Gene	tagSNP	MAF	Ca	Co	OR1	LCI	UCI	pcrude	pACT	ppathway	poverall	pHet
NHW (LABC)
BER	POLB	rs7832529	0.05	351	405	1.4	0.9	2.1	0.186	0.662	1.000	1.000
NER	POLD1	rs2244095	0.11	353	407	0.9	0.6	1.2	0.473	0.884	1.000	1.000
NER	POLD1	rs2546551	0.44	353	404	0.8	0.7	1.0	0.066	0.354	1.000	1.000
NER	XPC	rs2607734	0.43	355	409	1.0	0.8	1.3	0.857	1.000	1.000	1.000
NER	XPC	rs2279017	0.43	354	408	1.0	0.8	1.3	0.873	1.000	1.000	1.000
NER	XPC	rs2228001	0.43	352	409	1.0	0.8	1.3	0.773	1.000	1.000	1.000
Chinese (SBC)
BER	POLB	rs7832529	0.12	509	518	1.5	1.2	2.0	0.001	0.009	0.060	0.239
NER	POLD1	rs2244095	0.35	513	514	0.8	0.6	0.9	0.004	0.025	0.173	0.693
NER	POLD1	rs2546551	0.16	512	512	0.8	0.6	1.0	0.049	0.219	1.000	1.000
NER	XPC	rs2607734	0.36	514	520	1.3	1.1	1.6	0.002	0.020	0.141	0.562
NER	XPC	rs2279017	0.36	510	520	1.3	1.1	1.6	0.003	0.024	0.168	0.670
NER	XPC	rs2228001	0.36	513	521	1.3	1.1	1.6	0.004	0.028	0.197	0.788
NHW & Chinese (LABC & SBC)
BER	POLB	rs7832529		860	923	1.5	1.2	1.9	<0.001	0.003	0.021	0.084	0.564
NER	POLD1	rs2244095		866	921	0.8	0.7	0.9	0.003	0.018	0.125	0.500	0.350
NER	POLD1	rs2546551		865	916	0.8	0.7	0.9	0.009	0.049	0.342	1.000	0.676
NER	XPC	rs2607734		869	929	1.2	1.0	1.4	0.015	0.095	0.667	1.000	0.041
NER	XPC	rs2279017		864	928	1.2	1.0	1.4	0.018	0.111	0.778	1.000	0.044
NER	XPC	rs2228001		865	930	1.2	1.0	1.4	0.016	0.101	0.709	1.000	0.058

¹Per allele ORs and 95% CIs estimated from conditional logistic regression models assuming a log-additive mode of risk and adjusting for smoking status in reference year;

LCI = 95% lower confidence interval; UCI = 95% upper confidence interval; pcrude = unadjusted for multiple testing p-value; p_ACT = p-value corrected for multiple testing within gene region; p_pathway = p-value corrected for multiple testing within gene region and within pathway; p_overall = p-value corrected for testing across all SNPs and pathways; p-Het = LRT p-value from test of heterogeneity