Table 4.

XRCC6 rs2284082 × smoking interactions and bladder cancer risk among NHW from Los Angeles County & Shanghai Chinese

Smoking variables	Cases/Controls			CC				CT				TT
Smoking pack-yrs	CC	CT	TT	OR	LCI	UCI	p-value	OR	LCI	UCI	p-value	OR	LCI	UCI	p-value	Interaction p-values
Never	67/144	111/174	54/57	1.0				1.0				1.0				pcrude	0.001
< 24 pack-years	84/112	105/99	45/45	1.9	1.3	2.8	0.001	1.6	1.2	2.2	<0.001	1.4	0.9	2.3	0.151	pgene	0.003
≥ 24 pack-years	154/91	173/129	45/42	4.3	3.0	6.2	<0.001	2.4	1.9	3.2	<0.001	1.4	0.9	2.2	0.193	ppathway	0.020
p for trend							<0.001				<0.001				0.288	poverall	0.079
Years of smoking
Never	67/144	111/174	54/57	1.0				1.0				1.0				pcrude	0.001
<29	90/109	95/104	38/36	1.8	1.2	2.7	0.003	1.5	1.1	2.0	0.007	1.2	0.7	2.1	0.417	pgene	0.008
≥29	148/94	183/124	52/51	4.4	3.0	6.4	<0.001	2.6	2.0	3.4	<0.001	1.5	1.0	2.4	0.077	ppathway	0.046
p for trend							<0.001				<0.001				0.077	poverall	0.185
Cigarettes per day
Never	67/144	111/174	54/57	1.0				1.0				1.0				pcrude	0.015
<20	81/84	95/94	38/41	2.3	1.5	3.4	<0.001	1.7	1.3	2.2	<0.001	1.2	0.8	2.0	0.405	pgene	0.093
≥20	157/119	183/134	52/46	3.5	2.4	5.0	<0.001	2.3	1.8	3.0	<0.001	1.5	1.0	2.4	0.069	ppathway	0.556
p for trend							<0.001				<0.001				0.068	poverall	1.000
Smoking Status
Never	67/144	111/174	54/57	1.0				1.0				1.0				pcrude	<0.001
Former	78/118	87/100	30/31	1.6	1.1	2.4	0.022	1.4	1.1	1.9	0.021	1.3	0.7	2.1	0.394	pgene	0.001
Current	160/85	191/128	60/56	4.7	3.3	6.9	<0.001	2.6	2.0	3.4	<0.001	1.4	0.9	2.3	0.123	ppathway	0.008
p for trend							<0.001				<0.001				0.125	poverall	0.032

¹Per allele ORs and 95% CIs estimated from conditional logistic regression models with genotype coded as log-additive, adjusting for smoking status in reference year; LCI = 95% lower confidence interval; UCI = 95% upper confidence interval; p_clude = unadjusted for multiple testing p-value; p_gene = p-value corrected for multiple testing within gene region; p_pathway = p-value corrected for multiple testing within gene region and within pathway; p_overall = p-value corrected for testing across all SNPs and pathways.