Skip to main content
. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Nat Med. 2014 Apr 20;20(5):524–530. doi: 10.1038/nm.3542

Figure 4. Microbiota-derived signals regulate postnatal granulocytosis via TLR4 and MyD88 dependent pathway.

Figure 4

(a and c) Neonatal mice deficient in MyD88 (Myd88−/−) or TLR4 (Tlr4−/−) and age and sex matched wild type (WT) littermates exposed or not exposed to combination of 5 antibiotics (ABX) were examined for number of circulating neutrophils or (b and d) bone marrow neutrophils. (e) Administration of LPS (10 ng) to neonatal mice exposed to combination of 5 antibiotics (ABX) or no antibiotics (No ABX) via oral gavage and assessment of IL17 transcripts in small intestine or (f) plasma G-CSF (g) circulating neutrophils or (h) bone marrow neutrophils 48 h following gavage. Data are representative of three independent experiments with 8-10 mice per group. Results are shown as the means ± s.e.m.