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. 2014 May 9;9(5):e97137. doi: 10.1371/journal.pone.0097137

Figure 4. Heat Map of Altered Metabolites in the VISA, SG-R, Versus its Parent VSSA, SG-R and the revertant VSSA, SG-rev.

Figure 4

Heat map displaying the 12 metabolites whose abundance was significantly altered in the VISA isolate, SG-R compared against the parent VSSA, SG-S. Changes in abundance are indicated by color coding with red indicative of increases in mean intracellular abundance relative to the baseline (defined by the abundance in SG-S) and blue indicative of decreases in intracellular abundance on a log (2) scale. Specific p-values for the comparison of SG-R versus SG-S are denoted to the near right of the heat map. Metabolites are grouped according to pathway, denoted to the far right of each metabolite. Metabolites 1–7 reversed directionality in the revertant isolate (SG-rev) indicating a link to vancomycin resistance. Metabolites 8–12, however, did not reverse in SG-rev and are separated by a row to denote this difference. The superscript (a) denotes unable to determine if methylmalate or hydroxyglutarate in the absence of a chemical standard.