Skip to main content
. 2014 May 9;9(5):e97137. doi: 10.1371/journal.pone.0097137

Figure 5. Heat Map of Metabolites In Which Alterations in Intracellular Abundance was Linked to VISA-type Resistance.

Figure 5

Heat map displaying the 7 metabolites whose abundance was significantly altered in the VISA isolates from both series (SG-R and JH2) compared against the parent VSSA isolates (SG-S and JH1) and reversed directionality in the revertant, SG-rev, indicating a link to the vancomycin resistance phenotype. Of these seven metabolites, all but one (aminoadipate) changed in a similar fashion in both VISA isolates compared against the parent VSSA isolates. Changes in abundance are indicated by color coding with red indicative of increases in mean intracellular abundance relative to the baseline (defined by the abundance in SG-S) and blue indicative of decreases in intracellular abundance on a log (2) scale. Specific p-values for the comparison of SG-R versus SG-S are denoted to the near right of the heat map. The superscript (a) denotes unable to determine if methylmalate or hydroxyglutarate in the absence of a chemical standard.