Table 2.

Baseline scores of items assessing pain in RECOVER by severity of overall pain (Likert pain scale)

	‘Nocturnal cramps’ (from NADCS)	‘Painful muscle cramps or spasms due to PD’ (PDQ-8 item 7)	‘Pain in arms or legs’ (PDSS-2 item 10)	‘Muscle cramps in arms or legs’ (PDSS-2 item 11)	‘Painful posturing in the morning’ (PDSS-2 item 12)	‘Suffer from pain not explained by other known conditions’ (NMSS item 29)
‘No’ pain (n = 80) (pain score 0)	0.4 ± 0.8	0.8 ± 0.9	0.5 ± 0.9	0.6 ± 1.0	0.5 ± 0.9	0.6 ± 1.8
‘Mild’ pain (n = 87) (pain score 1–3)	0.7 ± 0.9 (p = 0.020)	1.3 ± 1.0 (p < 0.001)	1.1 ± 1.1 (p <0.001)	1.0 ± 1.1 (p = 0.007)	0.7 ± 1.0 (p = 0.139)	1.1 ± 2.1 (p = 0.062)
‘Moderate-to-severe’ pain (n = 100) (pain score ≥4)	1.1 ± 1.1 (p <0.0001)	1.7 ± 1.0 (p <0.0001)	1.9 ± 1.2 (p <0.0001)	1.5 ± 1.2 (p <0.0001)	1.4 ± 1.2 (p <0.0001)	2.1 ± 3.4 (p <0.001)

Data are mean ± SD. Data are presented for the FAS.

P values (t-test exploratory analyses) are reported for patients with ‘Mild’ pain and patients with ‘Moderate-to-severe’ pain vs patients with ‘No’ pain at baseline (assessed by the Likert pain scale).

FAS: full analysis set; NADSC: Nocturnal Akinesia, Dystonia and Cramps total score; NMSS: Non-Motor Symptoms Scale; PD: Parkinson’s disease; PDQ-8: 8-item Parkinson’s Disease Questionnaire; PDSS-2: Parkinson’s Disease Sleep Scale; RECOVER: Randomized Evaluation of the 24-hour Coverage: Efficacy of Rotigotine; SD: standard deviation.