Table 2.

Associations between renal factors and high sensitivity troponin t

		Unadjusted		Model 1		Model 2
	N*	Tobit ratio (95% CI)	P	Tobit ratio (95% CI)	P	Tobit ratio (95% CI)	P
eGFRcys* (ml/min/1.73 m 2 )
≥ 60	757	Reference	-	Reference		Reference	-
45-59	684	2.11 (1.86-2.41)	< 0.001	1.51 (1.35-1.69)	< 0.001	1.50 (1.34-1.67)	< 0.001
30-44	705	3.02 (2.66-3.44)	< 0.001	1.97 (1.74-2.22)	< 0.001	1.96 (1.74-2.21)	< 0.001
< 30	311	5.27 (4.47-6.21)	< 0.001	2.90 (2.47-3.41)	< 0.001	2.83 (2.41-3.33)	< 0.001
ACR (μg/mg) †
< 30	1115	Reference	-	Reference		Reference	-
30-299	582	1.58 (1.39-1.80)	< 0.001	1.08 (0.98-1.20)	0.130	1.06 (0.96-1.19)	0.214
300-999	338	1.94 (1.66-2.28)	< 0.001	1.09 (0.96-1.25)	0.191	1.08 (0.95-1.23)	0.238
≥ 1000	325	3.61 (3.08-4.23)	< 0.001	1.56 (1.35-1.81)	< 0.001	1.53 (1.32-1.77)	< 0.001
Phosphate (mg/dL)
< 3	265	Reference	-	Reference		Reference	-
3-3.9	1427	1.08 (0.90-1.28)	0.419	1.02 (0.90-1.17)	0.739	1.02 (0.90-1.17)	0.711
4-4.9	646	1.59 (1.31-1.93)	< 0.001	1.06 (0.91-1.23)	0.445	1.06 (0.92-1.24)	0.412
≥ 5	81	3.51 (2.52-4.90)	< 0.001	1.35 (1.04-1.76)	0.023	1.39 (1.08-1.81)	0.012
FGF-23 ‡
Quartile I	606	Reference		Reference		Reference
Quartile II	606	1.45 (1.25-1.68)	< 0.001	1.07 (0.96-1.20)	0.230	1.08 (0.96-1.21)	0.206
Quartile III	606	2.11 (1.82-2.45)	< 0.001	1.20 (1.06-1.35)	0.004	1.17 (1.04-1.33)	0.011
Quartile IV	606	2.62 (2.26-3.04)	< 0.001	1.22 (1.06-1.40)	0.004	1.17 (1.02-1.34)	0.021

*N’s are # observations among participants with TnT measurements, with 7 observation excluded.

Model 1 adjusted for: age (per SD), female, race, diabetes, SBP categories, albumin (per SD), eGFR_CysC, ACR, and phosphate and FGF-23. Model 2 adjusted for: Model 1 + LV mass, ejection fraction.

eGFRcys=cystatin-based estimated glomerular filtration rate. † albumin to creatinine ratio. ‡ fibroblast growth factor 23.