Table 3.
Associations between non-renal factors and high sensitivity troponin t
| |
|
Unadjusted |
Model 1 |
Model 2 |
|||
|---|---|---|---|---|---|---|---|
| N* | Tobit ratio (95% CI) | P | Tobit ratio (95% CI) | P | Tobit ratio (95% CI) | P | |
|
Age (per SD) |
2,457 |
1.39 (1.32-1.46) |
< 0.001 |
1.31 (1.25-1.37) |
< 0.001 |
1.31 (1.25-1.37) |
< 0.001 |
|
Female |
1,190 |
0.41 (0.37-0.46) |
< 0.001 |
0.38 (0.35-0.41) |
< 0.001 |
0.39 (0.36-0.42) |
< 0.001 |
|
Race |
|
|
|
|
|
|
|
| Non-Hisp white |
1,075 |
Reference |
- |
Reference |
- |
Reference |
- |
| Non-Hisp Black |
946 |
1.51 (1.34-1.70) |
< 0.001 |
1.31 (1.20-1.43) |
< 0.001 |
1.26 (1.16-1.38) |
< 0.001 |
| Hispanic |
330 |
2.09 (1.77-2.47) |
< 0.001 |
1.06 (0.93-1.21) |
0.398 |
1.02 (0.89-1.16) |
0.768 |
| Other |
106 |
1.10 (0.84-1.44) |
0.492 |
1.03 (0.84-1.25) |
0.807 |
1.02 (0.84-1.24) |
0.854 |
|
Diabetes |
1,009 |
2.96 (2.68-3.28) |
< 0.001 |
1.87 (1.71-2.04) |
< 0.001 |
1.84 (1.69-2.00) |
< 0.001 |
|
Albumin (per SD) |
2,437 |
0.72 (0.68-0.76) |
< 0.001 |
0.92 (0.88-0.96) |
0.001 |
0.93 (0.89-0.98) |
0.003 |
|
SBP (mmHg)* |
|
|
|
|
|
|
|
| < 120 |
408 |
Reference |
- |
Reference |
- |
Reference |
- |
| 120-129 |
324 |
1.32 (1.09-1.61) |
0.005 |
1.03 (0.89-1.19) |
0.678 |
1.03 (0.89-1.19) |
0.706 |
| 130-139 |
321 |
1.69 (1.39-2.05) |
< 0.001 |
1.14 (0.98-1.32) |
0.081 |
1.12 (0.97-1.29) |
0.139 |
| 140-149 |
194 |
2.03 (1.62-2.55) |
< 0.001 |
1.24 (1.05-1.47) |
0.014 |
1.22 (1.03-1.44) |
0.023 |
| 150-159 |
131 |
2.71 (2.09-3.51) |
< 0.001 |
1.44 (1.19-1.76) |
< 0.001 |
1.38 (1.14-1.69) |
0.001 |
| ≥ 160 |
163 |
3.36 (2.64-4.27) |
< 0.001 |
1.35 (1.12-1.63) |
0.001 |
1.27 (1.06-1.53) |
0.011 |
|
LV mass (g/m
2.7
) † |
|
|
|
|
|
|
|
| < 40 |
474 |
Reference |
- |
|
|
Reference |
- |
| 40-59 |
1,165 |
1.94 (1.68-2.24) |
< 0.001 |
|
|
1.17 (1.05-1.30) |
0.006 |
| 60-79 |
284 |
3.89 (3.20-4.72) |
< 0.001 |
|
|
1.39 (1.19-1.63) |
< 0.001 |
| 80-99 |
41 |
3.77 (2.49-5.72) |
< 0.001 |
|
|
1.47 (1.04-1.97) |
0.018 |
| ≥ 100 |
10 |
4.85 (2.15-10.95) |
< 0.001 |
|
|
1.87 (1.02-3.42) |
0.043 |
|
Ejection fraction (%) |
|
|
|
|
|
|
|
| > 50 |
1,845 |
Reference |
- |
|
|
Reference |
- |
| 46-50 |
197 |
1.12 (0.92-1.38) |
0.253 |
|
|
1.13 (0.98-1.31) |
0.087 |
| 36-45 |
130 |
1.33 (1.04-1.69) |
0.023 |
|
|
1.13 (0.95-1.34) |
0.184 |
| ≤ 35 | 22 | 1.93 (1.09-3.41) | 0.024 | 1.64 (1.09-2.48) | 0.018 | ||
*N’s are # observations among participants with TnT measurements, with 7 observation excluded.
Model 1 adjusted for: age (per SD), female, race, diabetes, SBP categories, albumin (per SD), eGFR_CysC, ACR, and phosphate and FGF-23. Model 2 adjusted for: Model 1 + LV Mass, ejection fraction. * Systolic blood pressure. † Left ventricular.