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. 2014 May 9;9(5):e97320. doi: 10.1371/journal.pone.0097320

Figure 6. Expression of an activated ErbB2 molecule mimics Nf2 loss in SC NPCs.

Figure 6

(A) Constitutively-activated ErbB2 (V659E) expression increases SC NPC neurosphere diameters (1.4-fold) (p = 0.0021; two-tailed Mann-Whitney U-test), (B) decreases NPC apoptosis (% cleaved caspase-3+ cells; 2.6-fold) (p<0.0001; two-tailed Mann-Whitney U-test), and (C) increases glial differentiation (2.6-fold) (p = 0.0006; two-tailed Mann-Whitney U-test). The data were normalized to the field of view. Values denote the mean ± SEM. (*) p<0.05; (**) p<0.001; (***) p<0.0001.