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. 2014 Apr 15;22(5):198–213. doi: 10.1007/s12471-014-0549-5

Table 4.

Ranolazine effects on ion currents in cardiomyocytes

Target Action Model Dose Block Author
Late I Na Inhibition Canine wedge preparations 6 μmol/L 50 % Antzelevitch 2004 [76]
Late I Ca Inhibition Canine wedge preparations 2–6 μmol/L 25–30 % Antzelevitch 2004 [76]
I ks Inhibition Canine wedge preparations 30 μmol/L 17 % Antzelevitch 2004 [76]
I Na-Ca Inhibition Canine wedge preparations 50 μmol/L 50 % Antzelevitch 2004 [76]
I kr Inhibition Canine wedge preparations 12 μmol/L 50 % Antzelevitch 2004 [76]