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. 2014 Mar 6;5:22. doi: 10.1186/2040-2392-5-22

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Copyright © 2014 Liu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Gene subnetworks for thePTEN,FOXP1 andSPAST genes. Figure shows all rASD genes with absolute correlation of.7 or better with (A)PTEN, (B)FOXP1 and (C)SPAST. Intensity of red color reflects the magnitude of the Z-score from the TADA statistic. Large nodes with labels depict genes that have at least one dnLoF mutation recorded in the current literature (except PTEN). ANK2, CUL3, DYRK1A, SCN2A and TBR1 are genes with multiple dnLoF mutations. ANK2 is included along with rASD genes because it has two dnLoF mutations.