Table 3.
Associations reported within included studies
| First author, year | Association | Analysis |
|---|---|---|
|
CKD and frailty associated with outcome | ||
| Wilhelm-Leen [14] |
• Mortality in frail patients with CKD |
HR 2.0, 95% CI 1.5 - 2.7 |
| • Frailty in patients with CKD stage 1/2 |
OR 2.21, 95% CI 1.49-3.28 |
|
| • Frailty in patients with CKD stage 3a |
OR 2.48, 95% CI 1.57-3.93 |
|
| • Frailty in patients with CKD stage 3b-5 |
OR 5.88, 95% CI 3.40-10.16 |
|
| Roshanravan [15] |
• Frailty components associated with Death or Dialysis |
HR 2.5, 95% CI 0.9-2.87 |
| • Frailty with eGFR between 30- 44 mL/min/1.73 m2 |
HR 2.1, 95% CI 1.0-4.7 |
|
| • Frailty with eGFR <30 mL/min/1.73 m2 |
HR 2.8, 95% CI 1.3-6.3 |
|
|
CKD and frailty associated | ||
| Odden [17] |
• Physical limitation with creatinine clearance between 60-90 mL/min |
OR 1.0, 95% CI 0.7-1.5 |
| • Physical limitation with creatinine clearance <60 mL/min |
OR 2.0, 95% CI 1.3-3.1 |
|
| • Low exercise capacity with creatinine clearance between 60-90 mL/min |
OR 2.3, 95% CI 1.4-3.8 |
|
| • Low exercise capacity with creatinine clearance <60 mL/min |
OR 6.7, 95% CI 3.8-11.8 |
|
| Shlipak [18] |
• Frailty in patients with CRI |
OR 1.76, 95% CI 1.28-2.41 |
| Fried [4] |
• Functional limitation in patients with CKD (eGFR <60 mL/min/1.73 m2) |
HR 1.30, 95% CI 1.08-1.56 |
| Bowling [19] |
• IADL decline with CKD stage≥3B (eGFR <45 mL/min/1.73 m2) |
OR 3.12, 95% CI 1.38-7.06 |
| • BADL decline with CKD stage≥3B (eGFR <45 mL/min/1.73 m2) |
OR 3.78, 95% CI 1.36-9.77 |
|
| Lattanzio [16] | • Low SPPB total score and eGFR | B = 0.49, 95% CI 0.18-0.66, p=0.003 |
BADL Basic Activities of Daily Living, CI confidence interval, CKD Chronic Kidney Disease, CRI chronic renal insufficiency, HR hazard ratio, IADL Instrumental activities of daily living, OR odds ratio, SPPB Short Physical Performance Battery.