Table 2.
Predictive factors associated with clinical CR to radiotherapy (n = 20)
| Characteristics | Complete response (No. of patients) | Partial response and stable disease (No. of patients) | Complete response rate | Crude odds ratio | 95% Confidence interval | P-value* |
|---|---|---|---|---|---|---|
| BED dose |
|
|
|
|
|
|
| ≥22 Gy |
3 |
4 |
43% |
4.44 |
0.62-32.07 |
0.14 |
| <22 Gy |
10 |
3 |
77% |
1 (Referent) |
|
|
| Underlying disease |
|
|
|
|
|
|
| Non-AML |
3 |
4 |
43% |
4.44 |
0.62-32.07 |
0.17 |
| AML |
10 |
3 |
77% |
1 (Referent) |
|
|
| Age |
|
|
|
|
|
|
| ≥50 y |
3 |
5 |
37.5% |
8.33 |
1.03-67.14 |
0.06 |
| <50 y |
10 |
2 |
83.3% |
1 (Referent) |
|
|
| Gender |
|
|
|
|
|
|
| Female |
5 |
4 |
55.6% |
2.13 |
0.33-13.81 |
0.64 |
| Male |
8 |
3 |
72.7% |
1 (Referent) |
|
|
| Cytogenetics |
|
|
|
|
|
|
| Abnormal |
6 |
4 |
60% |
1.56 |
0.24-9.91 |
1 |
| Normal |
7 |
3 |
70% |
1 (Referent) |
|
|
| Previous BMT before RT |
|
|
|
|
|
|
| Yes |
6 |
0 |
100% |
NA |
NA |
0.05 |
| No |
7 |
7 |
50% |
1 (Referent) |
|
|
| BM involvement at GS RT |
|
|
|
|
|
|
| Yes |
8 |
5 |
61.5% |
1.56 |
0.22-11.37 |
1 |
| No | 5 | 2 | 71% | 1 (Referent) |
Abbreviations: CR, complete remission; PR, partial response; SD, stable disease, BMT, bone marrow transplant; RT, radiotherapy; BM, bone marrow.
*Fisher’s exact test.