Table 3.
Predictive factors associated with clinical complete remission to radiotherapy (43 lesions analyzed using the GEE model)
| Characteristics | Complete response (No. of patients) | Partial response and stable disease (No. of patients) | Complete response rate | Univariate odds ratio | 95% Confidence interval | P-value |
|---|---|---|---|---|---|---|
| BED dose |
|
|
|
|
|
|
| ≥22 Gy |
6 |
4 |
60% |
1.15 |
0.20-6.63 |
0.88 |
| <22 Gy |
21 |
12 |
63.64% |
1 (Referent) |
|
|
| Underlying disease |
|
|
|
|
|
|
| Non-AML |
3 |
6 |
33.33% |
5.436 |
0.999-29.578 |
0.050 |
| AML |
24 |
10 |
70.59% |
1 (Referent) |
|
|
| Age |
|
|
|
|
|
|
| ≥50 y |
9 |
5 |
64.29% |
2.92 |
0.47-18.14 |
0.25 |
| <50 y |
18 |
11 |
62.07% |
1 (Referent) |
|
|
| Gender |
|
|
|
|
|
|
| Female |
7 |
5 |
58.33% |
1.41 |
0.31-6.36 |
0.65 |
| Male |
20 |
11 |
64.52% |
1 (Referent) |
|
|
| Cytogenetics |
|
|
|
|
|
|
| Abnormal |
13 |
10 |
56.52% |
1.35 |
0.27-6.83 |
0.72 |
| Normal |
14 |
6 |
70% |
1 (Referent) |
|
|
| Previous BMT before RT |
|
|
|
|
|
|
| Yes |
16 |
2 |
88.89% |
0.10 |
0.01-1.14 |
0.06 |
| No |
11 |
14 |
44% |
1 (Referent) |
|
|
| BM involvement at GS RT |
|
|
|
|
|
|
| Yes |
16 |
8 |
66.67% |
1.51 |
0.23-9.82 |
0.67 |
| No | 11 | 8 | 57.89% | 1 (Referent) |
Abbreviations: CR, complete remission; PR, partial response; SD, stable disease; RT, radiotherapy; BMT, bone marrow transplant; BM, bone marrow.