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. 2014 Mar 6;11:42. doi: 10.1186/1742-2094-11-42

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Copyright © 2014 Cui et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Overexpression of SOD1 in oligodendrocytes of mSOD1-Tg mice. (A-C) Immunoreactivity for SOD1 is observed in the nuclei and cytoplasm of oligodendrocytes in the anterior horns of non-Tg mice at 20 weeks of age and immunoreactivity for Cx47 is preserved at the surface of oligodendrocytes. (D-F) However, SOD1 is markedly accumulated in neurons and astrocytes in the anterior horns of mSOD1-Tg mice at 20 weeks of age and accumulation of SOD1 was also observed in oligodendrocytes with Cx47-immunopositivity in their cytoplasm (arrows). Membranous staining of Cx47 is not visible in abnormal-shaped oligodendrocytes. The nucleus is stained with DAPI (A-F blue). Scale bar; 5 μm (A-F).