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. 2014 Mar 6;11:42. doi: 10.1186/1742-2094-11-42

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Copyright © 2014 Cui et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Cleaved caspase-3 expression in the anterior horn oligodendrocytes of mSOD1-Tg mice. Double immunostaining for cleaved caspase-3 and CC1 was performed in the anterior horns of spinal cords from non-Tg and mSOD1-Tg mice at 20 weeks of age. (A-C) Immunoreactivity for cleaved caspase-3 is never observed in the anterior horn of non-Tg mice. (D-F) Cleaved caspase-3 expression is detected in a small number of CC1-positive mature oligodendrocytes in the anterior horns of mSOD1-Tg mice (arrows). Scale bar; 20 μm (A-F).