Table 1.
ROC analysis (sensitivity, specificity, and the AUC) comparing ten selected FISH probe parameters
| FISH probe parameters |
Tumour - BPH |
Histologically benign - BPH |
||||
|---|---|---|---|---|---|---|
| Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | |
| CEP8%Gain |
79.40% |
76.90% |
0.853 |
82.40% |
76.90% |
0.871 |
|
MYC%Gain |
91.20% |
76.90% |
0.908 |
82.40% |
76.90% |
0.846 |
| CEP7%Abnormal |
88.20% |
80.80% |
0.896 |
76.50% |
80.80% |
0.845 |
|
PTEN%Loss |
58.80% |
80.80% |
0.726 |
70.60% |
80.80% |
0.827 |
|
PTEN/CEP10%Loss |
82.40% |
80.80% |
0.881 |
64.70% |
80.80% |
0.788 |
| CEP10%Gain |
94.10% |
84.60% |
0.93 |
76.50% |
84.60% |
0.786 |
| CEP10%Abnormal |
79.40% |
80.80% |
0.865 |
76.50% |
73.10% |
0.775 |
| CEP7%Gain |
85.30% |
84.60% |
0.886 |
70.60% |
76.90% |
0.77 |
| CEP8%Abnormal |
94.10% |
88.50% |
0.966 |
64.70% |
76.90% |
0.752 |
| LPL%Abnormal | 79.40% | 92.30% | 0.945 | 64.70% | 76.90% | 0.736 |
The analyses of tumour ROI vs. BPH, and benign ROI vs. BPH performed independently. Sensitivity and specificity calculated at the optimal cut-off in each of the two analyses for each parameter.