Table 2.
ROC analysis of the selected four 4-probe combinations from the 10 single FISH probe parameters
| Probe combination | Probe parameters | Cut-off 1 | Cut-off 2 | Cut-off 3 | Cut-off 4 | Sensitivity | Specificity | AUC |
|---|---|---|---|---|---|---|---|---|
| Probe combination 1 |
PTEN%loss, CEP7%abnormal, MYC%gain, CEP8%abnormal |
33 PTEN% loss |
28 CEP7% abnormal |
35 MYC% gain |
34 CEP8% abnormal |
88.20% |
84.60% |
0.917 |
| Probe combination 2 |
PTEN/CEP10%loss, CEP7%abnormal, MYC%gain |
35 PTEN/CEP10% loss |
25 CEP7% abnormal |
35 MYC% gain |
NA |
82.40% |
80.80% |
0.911 |
| Probe combination 3 |
PTEN/CEP10%loss, CEP7%abnormal, CEP8%abnormal |
35 PTEN/CEP10% loss |
25 CEP7% abnormal |
34 CEP8% abnormal |
NA |
88.20% |
80.80% |
0.938 |
| Probe combination 4 | PTEN/CEP10%loss, MYC%gain, CEP8gain | 35 PTEN/CEP10% loss | 5 MYC% gain | 35 CEP8% gain | NA | 64.70% | 88.50% | 0.834 |
Cut-off 1, cut-off 2, cut-off 3, and cut-off 4 are the optimal probe cut-offs (providing lowest DFI), respectively.