Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb 17;14:99. doi: 10.1186/1471-2407-14-99

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Neiva et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Downregulation of IL-6 in tumor-associated endothelial cells inhibits tumor growth. A, ELISA for IL-6 expression in HDMEC transfected with shRNA-IL-6 or with a control scrambled oligonucleotide sequence (shRNA-C). B, xenograft human tumors were generated in SCID mice by co-implanting HeLa and HDMEC-shRNA-IL-6 or control HDMEC-shRNA-C. Tumors growth was analyzed with calipers every 2 days for the duration of the experiment. C, macroscopic view of two representative xenograft tumors per group. D-E, graphs depicting tumor volume (D) and tumor weight (E) after retrieval (28 days post-implantation). Asterisk depicts p < 0.05.