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. 2014 Feb 12;11:12. doi: 10.1186/1742-9994-11-12

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Copyright © 2014 Lengerer et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schematic illustration of an adhesive organ in controls and in macif1 dsRNA treated animals. Anchor cell (blue), adhesive (red) and releasing gland (green) within the epidermis (white). Five morphological alterations are obvious. 1) The microvilli core of macif1 dsRNA treated animals is closed in controls, whereas it appears open in treated animals. 2) The microvilli are shorter and 3) miss the dense core of actin filaments. 4) The treated animals lack intermediate filaments in the cytoplasm of anchor cells and 5) a reduced cytoplasmic interaction with hemidesmosomes is present.