Table 4.
Changes in plasma IL-6, sIL-6R, and TNF-α concentrations in depressed menopausal patients with undefined symptoms after treatment for three months with Kami-shoyo-san or anti-depressants
| Kami-shoyo-san | Anti-depressants | Significance | |||
|---|---|---|---|---|---|
| IL-6 |
|
|
|
|
|
| % change |
−29.1 ± 7.3% |
|
8.6 ± 6.5% |
|
P < 0.0001 |
| plasma level |
|
|
|
|
|
| before treatment |
1.88 ± 1.56 pg/ml |
]*1 |
2.06 ± 1.99 pg/ml |
]*3 |
NS |
| After 3-month treatment |
1.20 ± 0.85 pg/ml |
2.35 ± 3.79 pg/ml |
P = 0.04 |
||
| |
|
|
|
|
|
| sIL-6R |
|
|
|
|
|
| % change |
−17.6 ± 4.9% |
|
3.4 ± 6.1% |
|
P = 0.001 |
| plasma level |
|
|
|
|
|
| before treatment |
104.3 ± 25.5 ng/ml |
]*2 |
99.8 ± 29.5 ng/ml |
]*4 |
NS |
| 3-months treatment |
92.0 ± 33.7 ng/ml |
102.4 ± 32.7 ng/ml |
NS |
||
| |
|
|
|
|
|
| TNF-α |
|
|
|
|
|
| % change |
21.3 ± 5.4% |
|
−6.8 ± 2.2% |
|
P < 0.001 |
| plasma level |
|
|
|
|
|
| before treatment |
14.2 ± 6.3 pg/ml |
]*5 | 15.0 ± 6.6 pg/ml |
]*6 | NS |
| 3-months treatment | 17.2 ± 6.1 pg/ml | 14.5 ± 6.0 pg/ml | P < 0.05 | ||
*1: P = 0.02, *2: P = 0.02, *3: NS, *4: NS, *5: P < 0.0001, *6: NS.