Table 1.
Dutch lipid clinic network criteria
| Score | ||
|---|---|---|
|
Family history | ||
| First degree relative with known premature coronary and vascular disease (Men <55 yrs, Females <60 yrs), |
1 |
|
| OR |
|
|
| First degree relative with LDL cholesterol above the 95th percentile for age and sex |
|
|
| First degree relative with tendionous xanthomata and/or arcus cornealis, |
2 |
|
| OR |
|
|
| Children <18 yrs with LDL cholesterol above the 95th percentile for age and sex |
|
|
|
Clinical history | ||
| Patient with premature coronary artery disease (ages as above) |
2 |
|
| Patient with premature cerebral or peripheral vascular disease (ages as above) |
1 |
|
|
Physical examination | ||
| Tendinous xanthomata |
6 |
|
| Arcus cornealis prior to age 45 yrs |
4 |
|
| LDL cholesterol (mmol/L) |
|
|
| |
LDL-C ≥ 8.5 |
8 |
| |
LDL-C 6.5-8.4 |
5 |
| |
LDL-C 5.0-6.4 |
3 |
| |
LDL-C 4.0-4.9 |
1 |
| DNA analysis- functional mutation in the LDLR, APOB, or PCSK9 gene |
8 |
|
|
Stratification |
Total score |
|
| Definite FH |
≥8 |
|
| Probable FH |
6-7 |
|
| Possible FH |
3-5 |
|
| Unlikely FH | <3 | |
Modified from Civeira [3] with permission from Elsevier.