Table 1.
Decrease in antibody level 6 months after drug treatment stratified by age
| Age (years) | N | % pgp3 Ab + after 6 mos (CI) | P-value | N | % CT694 Ab + after 6 mos (CI) | P-value |
|---|---|---|---|---|---|---|
| |
|
IgG |
0.06 |
|
|
0.28 |
|
1 |
8 |
22.24 (4.24, 40.25) |
0.01 |
8 |
36.89 (10.46, 63.32) |
0.002 |
|
2 |
5 |
9.64 (−13.14, 32.41) |
0.83 |
6 |
32.25 (1.73, 62.77) |
0.03 |
|
3 |
14 |
4.94 (−8.67, 18.54) |
0.91 |
15 |
18.36 (−0.94, 37.67) |
0.07 |
|
4 |
22 |
9.07 (−1.79, 19.93) |
0.15 |
23 |
15.59 (0.00, 31.18) |
0.05 |
|
5 |
30 |
12.01 (2.72, 21.31) |
0.005 |
28 |
16.40 (2.27, 30.53) |
0.01 |
|
6 |
26 |
4.01 (−5.98, 14.00) |
0.86 |
25 |
0.60 (−14.36, 15.55) |
1.00 |
| |
|
IgA |
0.003 |
|
|
0.0006 |
|
1 |
7 |
60.08 (31.36, 88.80) |
<0.0001 |
6 |
75.06 (40.00, 100.00) |
<0.0001 |
|
2 |
5 |
60.11 (26.12, 94.10) |
<0.0001 |
4 |
68.85 (25.90, 100.00) |
0.0003 |
|
3 |
12 |
47.91 (25.97, 69.85) |
<0.0001 |
10 |
34.25 (7.08, 61.41) |
0.01 |
|
4 |
14 |
41.91 (21.60, 62.22) |
<0.0001 |
11 |
30.93 (5.03, 56.83) |
0.01 |
|
5 |
23 |
45.52 (29.67, 61.37) |
<0.0001 |
20 |
53.66 (34.45, 72.87) |
<0.0001 |
| 6 | 20 | 52.53 (35.53, 69.52) | <0.0001 | 17 | 53.01 (32.17, 73.84) | <0.0001 |
Values show the mean percentage drop in antibody median fluorescence intensity-background (MFI-BG) for IgG (top section) and IgA (bottom) from baseline to 6 months after drug treatment in paired samples. 95% confident intervals are shown in parentheses. P values testing for a difference from zero (no change) of < 0.05 were considered significant. P values in bold test for an average difference from zero across all age groups.