Figure 1.

NTG induces thermal hypersensitivity in wild-type and P2X7 knockout mice. The changes in nociceptive threshold after i.p. NTG treatment are presented on the graph, as PWT, expressed in % of baseline. PWT was decreased in animals that received 15 mg/kg NTG compared with animals that received vehicle (ANOVA, effect of treatment, F_1,41 = 37.34, p < 0.0001). NTG-induced decrease in PWT was not significantly different in wild-type and knockout mice. Asterisks denote significant changes between respective PWT values of vehicle- and NTG-treated mice (n = 10-13 animals/group; ANOVA + Fischer LSD post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001).