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. 2014 May 3;9:17. doi: 10.1186/1750-1326-9-17

Figure 3.

Figure 3

6-OHDA rapidly depolarizes mitochondria in both DA and non-DA axons. A) To ensure rapid, even labeling of mitochondria with TMRE (25 nM), axons were assessed after they had exited the microdevice channels. Scale bar indicates 10 μm. B) 6-OHDA significantly decreased mitochondrial membrane potential (ΔΨm) in DA and non-DA axons. Data indicate mean ± SEM from four independent experiments (n = 18–30 axons per group). ** indicates p < 0.001 versus control. C) Quantification of cross-sectional area of DA mitochondria before and after treatment with 6-OHDA. Data indicate mean ± SEM.