Scheme 1.
Reagents and conditions: (a) acetic anhydride, DMAP, anhydrous CH2Cl2, RT; (b) Br2, AlCl3, Et2O, ice bath; (c) NaHCO3, EtOH, reflux; (d) NaOH, THF/H2O, RT; (e) R1Cl, K2CO3, acetone, reflux or R2Cl, pyridine, 0 °C or RT
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