Figure 2.

First-trimester maternal serum levels of 250 kDa pregnancy-associated plasma protein A2 (PAPP-A2; measured via immunofluorescent Western blot) were significantly elevated in PE compared with control but not in PE/SGA or SGA, regardless of whether or not preterm samples (prior to 37 weeks, but at least 34 weeks, indicated by open symbols) were included. One sample (plus symbol) was from a pregnancy that subsequently developed PE and resulted in an SGA baby. Horizontal lines represent the least squares means from a general linear model including the effects of PE and SGA. PE indicates preeclampsia; SGA, small-for-gestational-age.