Table 6.
Recent examples of targeted nanoparticles using protein domains.
| PMID# | Protein | Target | Nanoparticle | Conjugation Chemistry |
|---|---|---|---|---|
| 17964677 | apolipoprotein B-100, LDLR binding domain | LDL Receptor | Micelle | Non-covalent interaction |
| 18076008 | C-termini of clostridium/botulinum neurotoxins (THC, BHC) | GT1b | ABCD NPs | Thiol/Maleimide |
| 19173297 | hepatitis B surface antigen (HBsAg), preS1 domain | HepG2 cell line | Micelle | Ester replacement |
| 20959824 | anti-IGFBP7 | GBM | PEG-Fe3O4 NPs | NHS ester |
| 21306773 | LFA-1, I domain | ICAM-1 | Liposome | Ni/His tag |
| 21609027 | 2Rb18a nanobody | HER2 | AuNPs | Thiol/Maleimide |
| 21609027 | N7 nanobody | PSA | AuNPs | Thiol/Maleimide |
| 21302357 | Affibody-EGFR | EGFR | Au-Silica NPs | Thiol/Maleimide |
| 21508310 | Affibody-EGFR | EGFR | Au-Silica NPs | Thiol/Maleimide |
| 21351748 | Affibody-HER2 | HER2 | Polymeric nanosphere | Amine/Carboxylate |
| 21147502 | Affibody-HER2 | HER2 | NIR QDs and IO NPs | Thiol/Maleimide |
| 20801029 | Affibody-HER2 | HER2 | Bionanocapsules (BNCs) | Genetically displayed |
| 19012296 | Affibody-HER2 | HER2 | PLA-PEG polymeric NPs | Thiol/Maleimide |
| 18937120 | Affibody-HER2 | HER2 | Thermosensitive liposomes | Thiol/Maleimide |
| 21753879 | adiponectin, globular domain (gAd) | Atherosclerotic plaques | Proticle | Non-covalent interaction |
| 21753879 | adiponectin, globular domain (gAd) | Atherosclerotic plaques | Liposome | Thiol/Maleimide |
| 22013169 | anti-IGFBP7 single-domain antibody | IGFBP7 | SPION | Amine/Carboxylate |
| 22037106 | Heptameric Z (EGFR) | EGFR | Ni-lipid NPs | Ni2+/His tag |
| 22118776 | Transferrin | Transferrin Receptor | HSA NPs | Thiol-maleimide |
| 22410170 | gp120 | DC-SIGN | PLGA | Biotin, streptavidin |