Table 7.
Recent examples of targeted nanoparticles using aptamers.
| PMID# | Aptamer | Aptamer Type | Target | Nanoparticle | Conjugation Chemistry |
|---|---|---|---|---|---|
| 15520166 | A10 | Modified RNA, 2′-F C/U, 3′ inverted dT cap | PSMA | PLA | Amine/Carboxylate |
| 16495043 | A9 | Modified RNA, 2′-F C/U | PSMA | Streptavidin Quantum Dots | Hydrazide |
| 18512972 | A9 | Unmodified RNA | PSMA | AuNPs | Base-pairing hybridization |
| 18978032 | A10 | Modified RNA, 2′-F C/U | PSMA | PLGA-b-PEG | Amine/Carboxylate |
| 19377681 | sgc8c | DNA | CCRF-CEM (T-cell acute lymphoblastic leukemia, T-cell ALL) cells | FCNPs | Amine/Carboxylate |
| 20024341 | sgc8 | DNA | CCRF-CEM (T-cell acute lymphoblastic leukemia, T-cell ALL) cells | Pegylated Liposome | Thiol/Maleimide |
| 20066302 | J18 | Unmodified RNA | EGFR | AuNPs | Base-pairing hybridization |
| 20080797 | TDO5 | DNA | immunoglobin heavy mu chain receptor | Aptamer-PEG-Lipid NPs | Non-covalent interaction |
| 20947949 | GB-10 | DNA | tenascin-c | Dextran Magnetic NPs | Amine/Carboxylate |
| 21233423 | A10 | Modified RNA, 2′-F C/U, 3′ inverted dT cap | PSMA | PLGA-b-PEG | Amine/Carboxylate |
| 21281497 | apt1 | Unmodified RNA, 2′-Ome termini | CD30 | PEI-citrate | Non-covalent interaction |
| 21342659 | MUC1 | DNA | MUC1 | Quantum Dot | Amine/Carboxylate |
| 21530479 | Ky2 | DNA | Kanamycin, kanamycin B, tobramycin | AuNPs | Non-covalent interaction |
| 21641946 | A9 | Unmodified RNA | PSMA | PAMAM dendrimer | Base-pairing hybridization |
| 21648076 | A9 | Unmodified RNA | PSMA | TCL-SPION | Amine/Carboxylate |
| 21732610 | MUC1 | DNA | MUC1 | Three-dimensional (3D) DNA polyhedra | Self-assembly |
| 21788069 | AS1411 | DNA | nucleolin | PEG-PLGA | Amine/Carboxylate |
| 21888350 | sgc8 | DNA | CCRF-CEM cell line | PHMNP | Amine/Carboxylate |
| 21912664 | MUC1 | DNA | MUC1 | PLGA | Amine/Carboxylate |
| 21936502 | A10 | Unmodified RNA | PSMA | QD–PMAT–PEI | Amine/Carboxylate, Thiol/Maleimide |
| 21942498 | sgc8c | DNA | CCRF-CEM cell line | AuNPs | Gold/Thiol |
| 21944470 | AS1411 | DNA | nucleolin | Magnetic Fluorescence NP (MF) | Amine/Carboxylate |
| 22214176 | XEO2 mini | Modified RNA, 2′-Ome C/A/U | PC3, LNCaP | DSPE-PLGA | Thiol/Maleimide |
| 22424140 | sgc8c | DNA | CCRF-CEM cell line | Streptavidin-coated MNPs | Biotin/Streptavidin |
| 22424140 | TDO5 | DNA | Ramos leukemia cell line | Streptavidin-coated MNPs | Biotin/Streptavidin |
| 22424140 | T2-KK1B10 | DNA | K562 leukemia cell line | Streptavidin-coated MNPs | Biotin/Streptavidin |
| 22424140 | KDED2a-3 | DNA | DLD1 colon cell line | Streptavidin-coated MNPs | Biotin/Streptavidin |
| 22424140 | KCHA10 | DNA | HCT116 colon cell line | Streptavidin-coated MNPs | Biotin/Streptavidin |
| 22424140 | TLS11a | DNA | LH86 liver cell line | Streptavidin-coated MNPs | Biotin/Streptavidin |