Table 1.
ECM1 expression, LMVD, and clinicopathological characteristics
| Clinicopathological parameters | N | |
ECM1 expression |
|
LMVD |
|
|---|---|---|---|---|---|---|
| - | + | P | (LMV per × 200 field) | P | ||
|
Gender |
|
|
|
0.618 |
|
0.627 |
| Male |
47 |
13 |
34 |
|
7.76 ± 1.21 |
|
| Female |
30 |
10 |
20 |
|
7.83 ± 1.23 |
|
|
Age (years) |
|
|
|
0.628 |
|
0.553 |
| <60 |
37 |
10 |
27 |
|
7.25 ± 1.17 |
|
| ≥60 |
40 |
13 |
27 |
|
8.34 ± 1.33 |
|
|
Differentiation degree |
|
|
|
0.489 |
|
0.253 |
| Low |
36 |
11 |
25 |
|
9.25 ± 1.37 |
|
| Moderate |
23 |
5 |
18 |
|
5.75 ± 1.22 |
|
| Well |
18 |
7 |
11 |
|
7.94 ± 2.01 |
|
|
Depth of invasion |
|
|
|
<0.0001*** |
|
0.721 |
| T1-T2 |
23 |
18 |
5 |
|
8.77 ± 1.97 |
|
| T3-T4 |
54 |
5 |
49 |
|
7.53 ± 0.99 |
|
|
Lymph node metastasis |
|
|
|
0.521 |
|
0.110 |
| 0 |
34 |
9 |
25 |
|
6.74 ± 1.29 |
|
| 1-2 |
18 |
9 |
11 |
|
7.00 ± 2.46 |
|
| 3-6 |
10 |
3 |
7 |
|
11.00 ± 2.74 |
|
| ≥7 |
15 |
4 |
11 |
|
9.57 ± 1.47 |
|
|
TNM stage |
|
|
|
0.0014** |
|
0.241 |
| 0-I |
21 |
12 |
9 |
|
8.50 ± 2.12 |
|
| II-III | 27 | 11 | 45 | 8.67 ± 1.18 |
‘+’, ‘++’, and ‘+++’ for ECM1 IHC staining are grouped together as ‘+’.
T1: lamina propria and submucosa; T2: muscularis propria and subserosa; T3: exposure to serosa; T4: invasion into serosa.
**P <0.01.
***P <0.001.
P <0.05 is considered statistically significant.