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Shown in A and B are Ewald refinements of two MAP kinase complexes with non-ATP inhibitors that bind at the FRS-site. A.) The structure of the α isoform of JNK1 in complex with inhibitor 46A bound (PDB ID: 3O2M), which exhibits extensive interactions with a second copy of itself within the asymmetric unit of the crystal. B.) A promising structure of p38 MAPKα with inhibitor 3NE bound (PDB ID: 3NEW).
