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. 2014 Feb 5;7(5):1068–1078. doi: 10.1038/mi.2013.123

Figure 5.

Figure 5

HES strongly suppresses early IL-33 production. (a–d) At 1, 24, and 48 h after Alternaria administration with or without HES, cell-free bronchoalveolar lavage (BAL) fluid was tested for levels of IL-5 (a), RELM-α (b), Ym1 (c), and IL-33 (d). Significance compares Alternaria level to Alternaria+HES level. (e) Alternaria, HES, and heat-treated HES (HT-HES) were administered to BALB/c mice and 1 h later levels of IL-33 in cell-free BAL fluid were measured. (f) Mean fluorescence intensity (MFI) of IL-33-Citrine within CD326+CD45.2– epithelial cells 12 h after Alternaria±HES administration. (g) MFI of IL-33-Citrine within CD326+CD45.2– epithelial cells 12 h after the final OVA administration in the Alternaria/OVA model shown in Figure 1a. Results are pooled from two repeat experiments, 3–5 mice per group. Unless otherwise indicated differences are not significant. ***P<0.01, **P<0.01, *P<0.05. HES, H. polygyrus excretory-secretory; OVA, ovalbumin.