Table 2.
Infectious diseases and malignancies in AIDS-associated autopsies
| |
All patients |
ART (−) patients |
ART (+) patients |
|
|
|||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | P values | ||
| Total |
225 |
100.0% |
136 |
100.0% |
66 |
100.0% |
|
|
| Infectious diseases |
|
|
|
|
|
|
|
|
| Cytomegalovirus |
142 |
63.1% |
97 |
71.3% |
25 |
37.9% |
<0.001 |
|
| Pneumocystis jirovecii pneumonia |
66 |
29.3% |
43 |
31.6% |
11 |
16.7% |
0.024 |
|
| Non-tuberculous mycobacterium |
31 |
13.8% |
20 |
14.7% |
8 |
12.1% |
0.618 |
|
| Candida |
25 |
11.1% |
17 |
12.5% |
6 |
9.1% |
0.474 |
|
| Aspergillus |
24 |
10.7% |
17 |
12.5% |
4 |
6.1% |
0.160 |
|
| Human immunodeficiency virus encephalopathy |
21 |
9.3% |
13 |
9.6% |
6 |
9.1% |
0.915 |
|
| Cryptococcus |
16 |
7.1% |
11 |
8.1% |
3 |
4.5% |
0.526 |
Y |
| Hepatitis B virus |
12 |
5.3% |
6 |
4.4% |
5 |
7.6% |
0.549 |
Y |
| Herpes simplex virus |
12 |
5.3% |
1 |
0.7% |
1 |
1.5% |
0.816 |
Y |
| Toxoplasmosis |
11 |
4.9% |
9 |
6.6% |
3 |
4.5% |
0.789 |
Y |
| Hepatitis C virus |
9 |
4.0% |
3 |
2.2% |
5 |
7.6% |
0.147 |
Y |
| Progressive multifocal leukoencephalopathy |
8 |
3.6% |
4 |
2.9% |
2 |
3.0% |
0.684 |
Y |
| Tuberculosis |
6 |
2.7% |
4 |
2.9% |
0 |
0.0% |
0.385 |
Y |
| Varicella zoster virus |
4 |
1.8% |
2 |
1.5% |
2 |
3.0% |
0.835 |
Y |
| Multicentric Castleman disease |
2 |
0.9% |
1 |
0.7% |
1 |
1.5% |
0.816 |
Y |
| Malignancies |
|
|
|
|
|
|
|
|
| Non Hodgkin lymphoma |
71 |
31.6% |
41 |
30.1% |
25 |
37.9% |
0.272 |
|
| Kaposi sarcoma |
38 |
16.9% |
22 |
16.2% |
10 |
15.2% |
0.852 |
|
| Endocervical cancer |
0 |
0.0% |
0 |
0.0% |
0 |
0.0% |
– |
|
| Non-AIDS defining malignancies |
20 |
8.9% |
10 |
7.4% |
10 |
15.2% |
0.082 |
|
| Hepatic cancer |
8 |
3.6% |
4 |
2.9% |
4 |
6.1% |
0.495 |
Y |
| Lung cancer |
6 |
2.7% |
2 |
1.5% |
4 |
6.1% |
0.174 |
Y |
| Leukemia |
2 |
0.9% |
0 |
0.0% |
2 |
3.0% |
0.200 |
Y |
| Hodgkin lymphoma |
2 |
0.9% |
1 |
0.7% |
1 |
1.5% |
0.816 |
Y |
| Gastric cancer |
1 |
0.4% |
1 |
0.7% |
0 |
0.0% |
0.711 |
Y |
| Other cancer | 3 | 1.3% | 3 | 2.2% | 0 | 0.0% | 0.551 | Y |
P values were calculated by Chi-square test. Y indicates the use of Chi-square test with Yates correction. Bold font indicates statistical significance. ART, antiretroviral therapy. Because more than one illness was detected in patients, the numbers of all illness are greater than the total number.