Table 2.
Average rank |
Left-sided p for low heterogeneity (restricted*) |
||||||
---|---|---|---|---|---|---|---|
Bin | Cytogenetic location | Observed | prank | pord | Q | Ha | B |
1.6 | 1p13.3-q23.3 | 93.34 | 0.004 | 0.439 | 0.782 (0.983) | 0.503 (0.894) | 0.464 (0.972) |
3.2 | 3p25.3-p22.1 | 92.52 | 0.006 | 0.151 | 0.580 (0.909) | 0.465 (0.851) | 0.443 (0.947) |
11.3 | 11p12-q13.3 | 89.02 | 0.014 | 0.218 | 0.630 (0.873) | 0.511 (0.800) | 0.363 (0.769) |
18.2 | 18p11-q12.3 | 88.72 | 0.014 | 0.087 | 0.006 (0.025) | 0.007 (0.026) | 0.007 (0.026) |
18.1 | 18pter-p11 | 85.51 | 0.028 | 0.232 | 0.140 (0.274) | 0.123 (0.234) | 0.087 (0.186) |
1.9 | 1q32-q42.3 | 84.88 | 0.030 | 0.157 | 0.111 (0.216) | 0.223 (0.378) | 0.115 (0.228) |
12.6 | 12q24.31-qter | 84.65 | 0.032 | 0.079 | 0.572 (0.743) | 0.516 (0.702) | 0.550 (0.802) |
11.4 | 11q13.3-q22.1 | 84.03 | 0.036 | 0.053 | 0.509 (0.673) | 0.511 (0.684) | 0.424 (0.653) |
Only bins with p value for average rank ≤0.05 in the weighted analyses are shown. Three heterogeneity statistics (Q, Ha, and B) are shown as described by Zintzaras and Ioannidis.(17) For heterogeneity, left-sided p < 0.05 signifies low heterogeneity and left-sided p ≥ 0.95 (right-sided p < 0.05) signifies high heterogeneity. The relative weights for the included studies are as follows: 0.15 for S1, 0.14 for S2, 0.06 for S3, 0.22 for S5, 0.17 for S6, 0.09 for S7, 0.08 for S8, and 0.09 for S9.
Heterogeneity metrics restricted for the average rank statistic of the pertinent bin.
pord, p value for the pord statistic; prank, p value for average rank.